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12 February 2020
Are you ready for Candida auris?
Multidrug resistant Candida auris emerged in 2009, and can cause invasive infections. But where did the superbug come from? And what should you be doing to prepare for it?
Blog by Nikki Kenters

Are you ready?

Multidrug resistant Candida auris emerged in 2009. So far, it has been identified in the countries displayed in Figure 1 below.1 C. auris想开一个红包扫雷群 can cause invasive infections (for example, bloodstream infections).

Figure 1: World map highlighting reported C. auris infections including single and multiple case reports, and outbreaks (published and unpublished). N. Kenters et al.

candida auris infection spread map

So, where did the superbug come from? One convincing theory involves global warming (Figure 2).2  With scientists predicting no stop to global warming, C. auris will likely keep on spreading worldwide. 

Figure 2. Proposed scheme for the emergence of C. aurisA. Casadevall et al.

Candida auris causes global warming

When I presented our work on C. auris at the IPS conference last September in Liverpool, I asked how many people from the audience would be ready for a first (un)expected C. auris case: only two hands were raised. Of course, there are some similarities between dealing with an unexpected case of C. auris in your hospital and dealing with the multidrug resistant bacteria and viruses that we are used to. However, C. auris想开一个红包扫雷群 is a fungus and there are some key differences. 

In the Netherlands, we already screen for multidrug resistant organisms (including VRE and MRSA) when patients have been admitted to an overseas hospital within the past two months. However, C. auris was not included in the standard screening. On top of that, C. auris is often misidentified.  

We have therefore developed, in an expert meeting, a set of recommendations on the most common interventions needed to handle a single case or outbreak of C. auris, including: screening policy, standard precautions, extra precautions, cleaning and disinfection, inpatient transfer, outbreak management, decolonization and treatment of C. auris (Table 1).1

Lessons learned:

  • For healthcare facilities to be prepared for a first case of C. auris, it is important to have a patient screening protocol, including a laboratory SOP, as well as adequate IPC procedures in place. Screening for C. auris differs from other multidrug resistant organisms. The screening sites most frequently culturing positively are the axilla and the groin (unpublished data, Schelenz et al.).
  • Any detection of C. auris should be immediately reported to your Infection Control department, leading to timely implementation of strict IPC measures.
  • Outbreak measures and screening should be instigated on detection of a previously unsuspected first case.
  • Patients colonised or infected with C. auris should be isolated until discharged and flagged for at least one year after the first negative screening culture.
  • Hospital administration should ensure availability and support for all IPC measures, while Infection Control departments should audit the correct use and application of the measures.

Table 1. Overview of infection prevention and control measures for C. auris cases and outbreaks. N. Kenters et al.

Candida auris IPC measures

*products need to meet the EN1500 testing standard

For cleaning and disinfection of the patients’ infected zone it is important to use a product that is effective against C. auris, for example hypochlorite or hydrogen peroxide <1%.

Hopefully in the near future all hospitals in the United Kingdom can be made ready for the possibility of a first C. auris case - especially now that a new superbug, Candida blankii, is emerging in India.3 On a neonatal unit four out of nine patients died of a Candida blankii infection.

想开一个红包扫雷群will this be the next candida superbug to take over the world? 

Nikki Kenters

Read our full article here:

  • Nikki Kenters, Martin Kiernan, Anuradha Chowdhary, David W. Denning, Javier Pemán, Katja Saris, Silke Schelenz, Ermira Tartari, Andreas Widmer, Jacques F. Meis, Andreas Voss, International Journal of Antimicrobial Agents. 2019, 54:4.

References:

1.  Nikki Kenters, Martin Kiernan, Anuradha Chowdhary, David W. Denning, Javier Pemán, Katja Saris, Silke Schelenz, Ermira Tartari, Andreas Widmer, Jacques F. Meis, Andreas Voss, International Journal of Antimicrobial Agents. 2019, 54:4. 10.1016/j.ijantimicag.2019.08.013

2. . Arturo Casadevall, Dimitrios P. Kontoyiannis, Vincent Robert. 

3. 想开一个红包扫雷群. Anuradha Chowdhary, J. Benjamin Stielow, Gargi Upadhaya, Pradeep K. Singh, Ashutosh Singh, Jacques F. Meis. Clinical Microbiology and Infection. 2020 (in press).

 

 


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